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Mouse Jarid2 Blocking Peptide (Center)

Mouse Jarid2 Blocking Peptide (Center)

ArtNr	ABC-BP21417c
Hersteller	Abcepta
Menge	500 ug
Kategorie	Peptides & Proteins Peptides
Typ	Peptides
Format	Lyophilized
Specific against	other
Citations	Takeuchi T.,et al.Genes Dev. 9:1211-1222(1995). Carninci P.,et al.Science 309:1559-1563(2005). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Motoyama J.,et al.Mech. Dev. 66:27-37(1997). Takeuchi T.,et al.Mech. Dev. 86:29-38(1999).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Protein Jumonji, Jumonji/ARID domain-containing protein 2, Jarid2, Jmj
Similar products	Jarid2, Jumonji/ARID domain-containing protein 2, Protein Jumonji, Jmj
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Primary Accession	Q62315
Bio Background	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Bio References	Takeuchi T., et al.Genes Dev. 9:1211-1222(1995). Carninci P., et al.Science 309:1559-1563(2005). Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Motoyama J., et al.Mech. Dev. 66:27-37(1997). Takeuchi T., et al.Mech. Dev. 86:29-38(1999).
Gene ID	16468
Gene Name	Jarid2
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence is selected from aa 435-448 of HUMAN Jarid2

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Menge: 500 ug

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