AMPK gamma (PRKAG1) Antibody (Center) Blocking peptide

PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.

5571

Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP7048c was selected from the Center region of human PRKAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.