GUCY2C Antibody (Center) Blocking Peptide

Peptides; Blocking Peptides

Guanylyl cyclase C (GC-C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GC-C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea. GUCY2C is a receptor for STa, and is also activated by the endogenous peptide guanylin. The GUCY2C receptor has an extracellular ligand-binding domain and a cytoplasmic guanylyl cyclase domain, as do members of the natriuretic peptide receptor family.

Synthetic peptide