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CDK8 Antibody (N-term) Blocking Peptide

ArtNr ABC-BP7524a
Hersteller Abcepta
Menge 500 ug
Kategorie
Typ Peptides
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products CDK8, Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
Lieferbar
Primary Accession
P49336
Bio Background
CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Bio References
Akoulitchev, S., et al., Nature 407(6800):102-106 (2000).Di Pietro, C., et al., Somat. Cell Mol. Genet. 25(3):185-189 (1999).Rickert, P., et al., Oncogene 18(4):1093-1102 (1999).Tassan, J.P., et al., Proc. Natl. Acad. Sci. U.S.A. 92(19):8871-8875 (1995).Schultz, S.J., et al., Cell Growth Differ. 4(10):821-830 (1993).
Gene ID
1024
Gene Name
CDK8
Subtitle
Synthetic peptide
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP7524a was selected from the N-term region of human CDK8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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Lieferung vsl. bis 02.10.2025 

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