VEGFR-3 (FLT4) Antibody (N-term) Blocking peptide

Peptides; Blocking Peptides

VGFR3, a member of the CSF-1/PDGF receptor subfamily of Tyr protein kinases, is a receptor for VEGFC. This Type I membrane protein is expressed in placenta, lung, heart, and kidney, but does not seem to be expressed in pancreas and brain. Defects in FLT4 are the cause of hereditary lymphedema I, also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. Defects in FLT4 are also found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.

Synthetic peptide