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ROR2 Antibody (N-term) Blocking Peptide

ArtNr ABC-BP7672a
Hersteller Abcepta
Menge 500 ug
Kategorie
Typ Peptides
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products ROR2, Neurotrophic tyrosine kinase, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2, receptor-related 2
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Primary Accession
Q01974
Bio Background
ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Bio References
Afzal, A.R., et al., Nat. Genet. 25(4):419-422 (2000).Oldridge, M., et al., Nat. Genet. 24(3):275-278 (2000).van Bokhoven, H., et al., Nat. Genet. 25(4):423-426 (2000).Schwabe, G.C., et al., Am. J. Hum. Genet. 67(4):822-831 (2000).Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992).
Gene ID
4920
Gene Name
ROR2
Subtitle
Synthetic peptide
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP7672a was selected from the N-term region of human ROR2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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