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DUSP10 Antibody (N-term) Blocking Peptide

DUSP10 Antibody (N-term) Blocking Peptide

ArtNr	ABC-BP8453a
Hersteller	Abcepta
Menge	500 ug
Kategorie	Peptides & Proteins Peptides
Typ	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	DUSP10, MKP5, Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MKP-5, MAP kinase phosphatase 5
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Primary Accession	Q9Y6W6
Bio Background	Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.
Bio References	Tanoue, T., et al., J. Biol. Chem. 274(28):19949-19956 (1999).Theodosiou, A., et al., Oncogene 18(50):6981-6988 (1999).Martell, K.J., et al., Mol. Cells 8(1):2-11 (1998).Masuda, K., et al., Cytogenet. Cell Genet. 90 (1-2), 71-74 (2000) (): ().
Gene ID	11221
Gene Name	DUSP10
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP8453a was selected from the N-term region of human DUSP10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

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ABC-BP8453a-datasheet.pdf

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Menge: 500 ug

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Lieferung vsl. bis 04.09.2025

Express-Lieferung: 29 Tage sparen

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