Thymosin alpha1 Acetate

Thymosin a1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ -cm H2O not less than 100 µ g/ml, which can then be further diluted to other aqueous solutions. The protein (1mg/ml) was lyophilized with no additives. Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18° C. Upon reconstitution Thymalfasin should be stored at 4° C between 2-7 days and for future use below -18° C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.

Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH

C129H215N33O55

thymosin-alpha-1, thymosin a1, thymalfasin, Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH