ADRBK1 Recombinant Protein

Protein

Root Catalog/Products/Recombinant Proteins

58.28kDa

G protein-coupled receptor kinase 2

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).

NP_001610.2

200 ug/mL (prior to lyoph)