Anti-TRAF6 Antibody

Primary Antibodies

59573 MW

TRAF6 antibody can be used for detection of TRAF6 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

TNF receptor-associated factor 6

TRAF6 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6. The immunogen is located within the last 50 amino acids of TRAF6.

TRAF6 Antibody is Ion exchange chromatography purified.

Signal Transduction

E3 ubiquitin ligase that, together with UBE2N and
UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin
chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and
AKT2. Also mediates ubiquitination of free/unanchored
polyubiquitin chain that leads to MAP3K7 activation. Leads to the
activation of NF-kappa-B and JUN. May be essential for the
formation of functional osteoclasts. Seems to also play a role in
dendritic cells (DCs) maturation and/or activation. Represses c-
Myb-mediated transactivation, in B-lymphocytes. Adapter protein
that seems to play a role in signal transduction initiated via TNF
receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast
differentiation by mediating the activation of adapter protein
complex 1 (AP-1) and NF-kappa-B, in response to RANK-L
stimulation. Together with MAP3K8, mediates CD40 signals that
activate ERK in B-cells and macrophages, and thus may play a role
in the regulation of immunoglobulin production.

Boster Bio Anti-TRAF6 Antibody (Catalog # A00185-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Bovine, Pig