Anti-Integrin alpha 4 ITGA4 Antibody

Integrin alpha 4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

ITGA4

At least two isoforms are known to exist. The immunogen to this antibody is outside of the Integrin alpha4 recombinant protein fragment and thus will not recognize it.

Integrin alpha 4 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Integrin alpha 4. The immunogen is located within the last 50 amino acids of Integrin alpha 4.

Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.

Infectious Diseases

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are
receptors for fibronectin. They recognize one or more domains
within the alternatively spliced CS-1 and CS-5 regions of
fibronectin. They are also receptors for VCAM1. Integrin alpha-
4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-
4/beta-7 is also a receptor for MADCAM1. It recognizes the
sequence L-D-T in MADCAM1. On activated endothelial cells integrin
VLA-4 triggers homotypic aggregation for most VLA-4-positive
leukocyte cell lines. It may also participate in cytolytic T-cell
interactions with target cells. ITGA4:ITGB1 binds to fractalkine
(CX3CL1) and may act as its coreceptor in CX3CR1-dependent
fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to
PLA2G2A via a site (site 2) which is distinct from the classical
ligand-binding site (site 1) and this induces integrin
conformational changes and enhanced ligand binding to site 1
(PubMed:18635536, PubMed:25398877).

Boster Bio Anti-Integrin alpha 4 ITGA4 Antibody (Catalog # A00468). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

At least two isoforms are known to exist. The immunogen to this antibody is outside of the Integrin alpha4 recombinant protein fragment and thus will not recognize it.