Anti-Bim BCL2L11 Antibody

Bim antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

BCL2L11

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

Bim Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

BCL2-like 11 (apoptosis facilitator)

Endomembrane system;
Peripheral membrane protein. Associated with
intracytoplasmic membranes.

Isoform BimEL, isoform BimL and isoform BimS
are the predominant isoforms and are widely expressed with tissue-
specific variation. Isoform Bim-gamma is most abundantly expressed
in small intestine and colon, and in lower levels in spleen,
prostate, testis, heart, liver and kidney.