Anti-IPR1 SP110 Antibody

IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

SP110

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

IPR1 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

SP110 nuclear body protein

Nucleus

Highly expressed in peripheral blood
leukocytes and spleen. Detected at intermediate levels in thymus,
prostate, testis, ovary, small intestine and colon, and at low
levels in heart, brain, placenta, lung, liver, skeletal muscle,
kidney and pancreas.