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Human LILRB4 / CD85k / ILT3 Protein, Fc Tag (MALS verified) Europäischer Partner

Hersteller ACROBiosystems
Kategorie
Typ Proteins
Specific against Human
Format Powder
Menge 1mg
ArtNr LI4-H5256-1mg
Konjugat/Tag Fc Tag
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Bioactivity Legend 1
Immobilized Human LILRB4, Fc Tag (Cat. No. LI4-H5256) at 1 μg/mL (100 μL/well) can bind Anti-LILRB4 Antibody, Human IgG1 with a linear range of 0.4-6 ng/mL (QC tested).
Buffer
PBS, pH7.4
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Description
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Endotoxin Level
Less than 1.0 EU per μg by the LAL method.
Exp Region
Gln 22 - Glu 259
Expression System
HEK293
Molecular Weight
52.7 kDa
Molecule
LILRB4
SDS-PAGE Legend
Human LILRB4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Storage
-20℃

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1mg
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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