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Human SIRP alphaV2 / CD172a (31-148) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified) Europäischer Partner

Hersteller ACROBiosystems
Kategorie
Typ Proteins
Specific against Human
Format Powder
Menge 1mg
ArtNr SI2-H5257-1mg
Konjugat/Tag Llama IgG Fc Tag
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Bioactivity Legend 1
Immobilized Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. SI2-H5257) at 5 μg/mL (100 μL/well) can bind Human CD47, His Tag (Cat. No. CD7-H5227) with a linear range of 0.02-0.313 μg/mL (QC tested).
Bioactivity Legend 2
Immobilized Human CD47, His Tag (Cat. No. CD7-H5227) at 5 μg/mL (100 μL/well) can bind Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. SI2-H5257) with a linear range of 0.2-5 ng/mL (Routinely tested).
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Characteristics
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Description
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Endotoxin Level
Less than 0.01 EU per μg by the LAL method.
Exp Region
Glu 31 - Ser 148
Expression System
HEK293
Molecular Weight
40.6 kDa
Molecule
SIRP alphaV2
SDS-PAGE Legend
Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Storage
-20℃

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1mg
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 06.06.2024 

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