Hamster Anti Mouse CTLA-4 (CD152)

CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

mixture of mouse activated T cells.

1mg/ml in PBS (after reconstitution)

This antibody is only available as purified antibody.

Lyophilized: store at 4C. After reconstitution, if not intended for use within a month, aliquot and store at -20C.