Recombinant Human Insulin Like Growth Factor Binding Protein-3

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Escherichia Coli.

Lyophilized from a0.2um filtered concentrated (0.5mg/ml) solution in PBS, pH 7.4.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

The ED_50, calculated by by its ability to inhibit IGF-II induced proliferation of MCF-7 is 0.2 ug/ml in the presence of 15 ng/ml of Human IGF-II, corresponding to a specific activity of 5, 000, 000units/mg.