Recombinant Human Insulin Like Growth Factor Binding Protein-5

IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Escherichia Coli.

IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10mM sodium Citrate pH-3 .

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The ED₅₀, calculated by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is 0.4 g/ml, corresponding to a specific activity of 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.