Recombinant Human Signal Transducer and Activator of Transcription 1

STAT1 is a member of the Signal Transducers and Activators of Transcriptionfamily of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type Ior type IIinterferons. In response to IFN-stimulation, STAT1 forms homodimers or heterodimers with STAT3that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element, in response to either IFN- or IFN-stimulation, STAT1 forms a heterodimer with STAT2that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).

Escherichia Coli.

STAT1 0.5mg/ml protein solution contains 20mM Tris-HCl buffer pH-8, 0.1M Nacl, 1mM DTT and 10% glycerol.

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