Recombinant Human Interferon Induced With Helicase C Domain 1

IFIH1 is a DEAD box protein which is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be attained by therapy with both these agents, treatment with either agent alone only achieves reversible differentiation. DEAD box proteins are implicated in several cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Genetic variation in the IFIH1 gene is linked with diabetes mellitus insulin-dependent type 19.

Sf9 Insect Cells.

IFIH1 is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.

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