Human CD40/TNFRSF5 protein, His tag (Animal-Free)

The recombinant human CD40 protein consists of 179 amino acids and predicts a molecular mass of 20 kD.The apparent molecular mass of the human CD40 is approximately 25-33 kDa in SDS-PAGE under reducing conditions due to glycosylation.

>95% as determined by SDS-PAGE

Endotoxin: < 1 EU per ug of the protein as determined by the LAL method.

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized human CD40 protein in the buffer which we provide not less than 100 ug/mL, which can then be further diluted to other aqueous solutions.

The product is shipped at ambient temperature.

CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications.

B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

CD40/TNFRSF5