Recombinant Human EGFR Protein, His Tag

EGFR

P00533

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

As a member of the epidermal growth factor receptor tyrosine kinases subfamily, EGF R is a type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR signaling plays a crucial role in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR homo- or hetero- dimerization, initiates subsequent tyrosine autophosphorylation and various downstream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling has been shown to exert actions on carcinogenesis and disease progression, and thus EGFR was proposed as a target for cancer therapy currently.

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