Recombinant Human IL8/CXCL8 Protein, Fc Tag

CXCL8

P10145

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

IL-8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor 4, GRO, IP1, etc. IL-8 is a potent chemoattractant for neutrophils. In addition, IL-8 also has a wide range of other proinflammatory effects. IL-8 causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a comitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.

This product is shipped on ice packs or dry ice.