Recombinant Human CD33 Protein, His Tag

CD33

P20138

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

Myeloid?cell?surface?antigen CD33 also known as SIGLEC3, Siglecs?(sialic?acid?binding?Ig-like?lectins) and?GP67, is a single-pass type I membrane protein which belongs to the?immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

This product is shipped on ice packs or dry ice.