Recombinant Human CD57/B3GAT1 Protein, His Tag

B3GAT1

Q9P2W7

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

B3gat1 is a keyenzyme involved in human natural killer-1 (HNK-1) epitope synthesis. It addsa glucuronic residue to the terminal lactosamine residue (Galbeta1-4GlcNAc-) ofa glycoprotein or glycolipid, which can be further sulfated to become the HNK1 epitope, a unique trisaccharide structure, HSO3-3GlcAbeta1-3Galbeta1-4GlcNAc-.The enzyme activity was found to be enhanced in the presence of sphingomyelinand phosphatidylinositol.The B3gat1 carbohydrate epitope ischaracteristically expressed on a series of cell adhesion molecules in additionto some glycolipids in the extracellular matrix and on the cell surface inthe nervous system, where it is involved in cell-cell and cellsubstratum interactionand recognition during the development of the nervous system.

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