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Recombinant Human CD220/INSR Protein, His Tag

ArtNr KMD-KMH382-50ug
Hersteller KMD Bioscience
Menge 50 ug
Kategorie
Typ Proteins Recombinant
Specific against Human (Homo sapiens)
Host Mammalian cell
Konjugat/Tag His
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias HHF5, CD220, insulin receptor
Lieferbar
Molecular Name
INSR
Source
This protein contains the human INSR(Met1-Ser758) was fused with the C-terminal His Tag and expressed in Mammalian cells.
Uniprot Accession
P06213
Purity
>=90% as determined by SDS-PAGE
Endotoxin
< 1.0 EU per ug of the protein as determined by the LAL method.
Buffer
PBS
Purification
Protein A/G
Predicted Molecular Weight
83.38kDa
Background
InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, alpha and beta that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas beta cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult beta cells and the central control of nutrient homeostasis.
Storage
Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition
This product is shipped on ice packs or dry ice.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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