Recombinant Human Heregulin-β1 (HRG1-β EGF Domain) - 50 µg

Recombinant Proteins

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Neuregulin/Heregulin is a family of related growth factors that are differentially spliced variants of four genes: NRG1, NRG2, NRG3 and NRG4. The longest forms of NRG contains several different modular domains and tissue-specific splicing results in many NRG isoforms containing different sets of these domains. Alternative splicing produces two types of EGF domain, designated a and b. HRG-Beta1 contains an Ig domain and an EGF domain necessary for direct binding to receptor tyrosine kinases erbB-3 and erbB-4. HRG-Beta1 binding causes erbB-3 and erbB-4 to dimerize with erbB-2 (Her2/neu) and thereby regulates the phosphorylation of erbB-2 tyrosines. HRG-Beta1 stimulates proliferation and motility of breast cancer cells and plays a role in wound healing by stimulating epidermal migration and differentiation of epidermal cells and by stimulating the expression of integrins in the epidermis.

Recombinant Protein, Heregulin 1-β1, Neuregulin1-β1 [NRG-β1], HRG, Breast Cancer Cell Differentiation Factor p45, Acetylcholine Receptor Inducing Activity [ARIA], Glial Factor, Neu Differentiation Factor, HRG1-β1, Human HRG1-β1, Recombinant Human Heregulin-β1 (HRG1-β), ARIA; GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, neuregulin 1, Neuregulin1 beta 1, Neuregulin-1 beta 1, NRG1-IT2, SMDF