Vergleich

TL1A / TNFSF15 Recombinant Protein

ArtNr PRS-11-109-0.1mg
Hersteller ProSci
Menge 0.1 mg
Kategorie
Typ Proteins Recombinant
Format Lyophilized
Applikationen WB, ELISA
Specific against other
Konjugat/Tag HIS
Purity >90% as determined by SDS-PAGE.
Sequence Leu 72- Leu 251
NCBI TNFSF15
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TL1A, VEGI-251, TNFSF15
Lieferbar
Manufacturer - Applications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Conditions
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
22.4 kDa
Background
TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.
Buffer
PBS, pH7.4
NCBI Official Name
TNFsuperfamilymember15
NCBI Organism
Homo sapiens
Disclaimer
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1 mg
Lieferbar: In stock
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