Vergleich

ICOS / CD278 (C137S, C138S) Recombinant Protein

ArtNr PRS-11-360-0.1mg
Hersteller ProSci
Menge 0.1 mg
Kategorie
Typ Proteins Recombinant
Format Lyophilized
Applikationen WB, ELISA
Specific against other
Konjugat/Tag HIS
Purity >90% as determined by SDS-PAGE.
Sequence Glu 21 - Leu 144
Citations Hutloff A., et al., 1999, Nature 397:263-266.
Tezuka K., et al., 2000, Biochem. Biophys. Res. Commun. 276:335-345.
Beier K.C., et al., 2000, Eur. J. Immunol. 30:3707-3717.
NCBI Icos
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias ICOS,CD278,AILIM,Inducible T-cell costimulator
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Recombinant Proteins
Shipping Temperature
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight
15.7 kDa
Background
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Buffer
PBS, pH7.4
Application Note
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
inducible T cell co-stimulator
NCBI Organism
Mus musculus
Disclaimer
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species
Mouse
By Species
Mouse

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1 mg
Lieferbar: In stock
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