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IL-1alpha Recombinant Protein

IL-1alpha Recombinant Protein

ArtNr	PRS-90-461-50ug
Hersteller	ProSci
Menge	50 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines
Typ	Proteins Recombinant
Format	Lyophilized
Specific against	other
Konjugat/Tag	HIS
Purity	>98% (SDS-PAGE).<br><br> Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Sequence	Human IL-1alpha (aa 113-271) is fused at the C-terminus to a His-tag.
NCBI	IL1A
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Interleukin-1alpha,IL-1F1,IL-1A
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Background	The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
By Type	Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Neuroscience, Obesity, Signal Transduction
Protein Gi #	27894330
Buffer	Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 100mM NaCl. Reconstituted in sterile H2O not less than 100 μ g/ml, which can then be further diluted in other aqueous solutions.
Application Note	This recombinant proteins is for research use only.
NCBI Official Name	interleukin 1 alpha
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 50 ug

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Lieferung vsl. bis 01.01.2026

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