« Zurück
Startseite /
TNFR1 Recombinant Protein

TNFR1 Recombinant Protein

ArtNr	PRS-96-727-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis By Cell Type Melanoma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Western Blot
Typ	Proteins Recombinant
Format	Lyophilized
Applikationen	WB
Specific against	other
Konjugat/Tag	HIS
Purity	>92% as determined by SDS-PAGE.
Sequence	Ile 22 - Thr 211
Citations	Jiang Y., et al., 1999, Science 283:543-546. Le V.T., et al., 2011, J. Virol. 85:13260-13270. Gregory A.P., et al., 2012, Nature 488:508-511.
NCBI	TNFRSF1A
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight	22.3 kDa
Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized human TNFa at 5μ g/mL (100μ l/well) can bind human TNFR1 / CD120a. The EC50 of human TNFR1 is 510 ng/mL.
Background	Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
By Type	Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction, Other, Inflammasomes
Buffer	PBS, pH7.4
Application Note	This recombinant protein can be used for WB. For research use only.
NCBI Official Name	tumor necrosis factor receptor superfamily, member 1A
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.1 mg

lieferbar

Lieferung vsl. bis 04.12.2025

Express-Lieferung: 24 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern