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TNF alpha Recombinant Protein (HEK293 Expressed)

TNF alpha Recombinant Protein (HEK293 Expressed)

ArtNr	PRS-96-734-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Western Blot By Organ Thyroid Cancer
Typ	Proteins Recombinant
Format	Lyophilized
Applikationen	WB
Specific against	other
Konjugat/Tag	Tag Free
Purity	>95% as determined by SDS-PAGE.
Sequence	Val 77 - Leu 233
Citations	Dowlati Y, Herrmann N, et al., 2010, Biol Psychiatry 67 (5): 446–457. Swardfager W, Lanctot K, et al., 2010, Biol Psychiatry 68 (10): 930–941. Locksley RM, Killeen N et al., 2001, Cell 104 (4): 487–501.
NCBI	TNF
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight	17.4 kDa
Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized Human TNF-alpha at 5 ug/mL (100 ul/well) can bind Humira with a linear range of 0.04-0.6 ng/mL. The bio-activity was determined by its cytotoxcity assy using L929 Cells with 1ug/ml actinomycin D.
Background	Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
By Type	Apoptosis, Cancer, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Obesity, Signal Transduction
Buffer	PBS, pH7.4
Application Note	This recombinant protein can be used for WB. For research use only.
NCBI Official Name	tumor necrosis factor
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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Lieferung vsl. bis 04.12.2025

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