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Anti-Histone H4 Rabbit mAb

Anti-Histone H4 Rabbit mAb

ArtNr	PTM-1015RM
Hersteller	PTM Biolabs
Menge	100 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Lyophilized powder
Applikationen	WB, IHC-P
Clon	PA-187-63
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Monkey (Cynomolgus, Simian), Pig (Porcine, Sus scrofa domesticus), Yeast (Saccharomyces cerevisiae)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Hao-Min An, et al. MYST family histone acetyltransferases regulate reproductive diapause initiation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023. https://www.sciencedirect.com/science/article/pii/S0141813023051681.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	H4C1, H4/A, H4FA, HIST1H4A, H4C2, H4C3, H4C4, H4C5
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H4
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	11
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Epigenetics
Manufacturer - Reactivity	Human, Mouse, Rat, Monkey, Pig, S. cerevisiae
Product description	Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Histone proteins not only serve to compact chromosomal DNA but also play vital roles in the dynamic and long-term regulation of genes by a wide variety of post-translational modifications (PTMs). These PTMs including acetylation, methylation, phosphorylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription. Histone H4 is primarily acetylated at Lys5, 8, 12, and 16, and methylated at Lys20.
Purification Method	Protein A purified
Manufacturer - Specificity	Anti-Histone H4 Rabbit mAb detects endogenous levels of total histone H4 protein. It does not cross-react with other histone or non-histone proteins.
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Immunogen	Synthetic peptide corresponding to the C-terminus of human histone H4 protein
Clonality	Recombinant Monoclonal
Background	Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Histone proteins not only serve to compact chromosomal DNA but also play vital roles in the dynamic and long-term regulation of genes by a wide variety of post-translational modifications (PTMs). These PTMs including acetylation, methylation, phosphorylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription. Histone H4 is primarily acetylated at Lys5, 8, 12, and 16, and methylated at Lys20.
Cellular Localization	Nucleus

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Menge: 100 ul

lieferbar

Lieferung vsl. bis 25.09.2025