Anti-Phospho-(Ser/Thr) PDK1 Docking Motif Mouse mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine in a hydrophobic motif. For example, Akt, a kinase that regulates cell survival, is activated by phosphorylation at Ser473, a site preceded by Phe at -4 and -1 and followed by Tyr at +1. RSK2, p70 S6 kinase and certain PKC isoforms also contain a similar consensus phosphorylation motif. Phosphorylation of these motifs is required for binding to 3-phosphoinositide-dependent kinase 1 (PDK1). Anti-Phospho-(Ser/Thr) PDK1 Docking Motif Mouse mAb is a powerful tool for the characterization of phosphorylated PDK1 docking motifs and the identification of new proteins with PDK1 docking motifs.

PBS, Glycerol, BSA

Ser, Thr

Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine in a hydrophobic motif. For example, Akt, a kinase that regulates cell survival, is activated by phosphorylation at Ser473, a site preceded by Phe at -4 and -1 and followed by Tyr at +1. RSK2, p70 S6 kinase and certain PKC isoforms also contain a similar consensus phosphorylation motif. Phosphorylation of these motifs is required for binding to 3-phosphoinositide-dependent kinase 1 (PDK1). Anti-Phospho-(Ser/Thr) PDK1 Docking Motif Mouse mAb is a powerful tool for the characterization of phosphorylated PDK1 docking motifs and the identification of new proteins with PDK1 docking motifs.