Anti-Ras Mouse mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Ras is a 21 kDa guanine-nucleotide binding proteins. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.

PBS, Glycerol, BSA

Recombinant Monoclonal

Cell membrane, Golgi apparatus, Cytoplasm, Nucleus