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Anti-beta-Amyloid (1-40) Rabbit pAb

Anti-beta-Amyloid (1-40) Rabbit pAb

ArtNr	PTM-6844
Hersteller	PTM Biolabs
Menge	100 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized powder
Applikationen	WB, IHC-P
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Beta-APP40
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	beta-Amyloid (1-40)
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Neuroscience
Product description	β-Amyloid (Aβ) precursor protein (APP) is a 100 - 140 kDa transmembrane glycoprotein that exists as several isoforms The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage. The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease. APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein. Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase. APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation. β -amyloid (1-40) Rabbit pAb recognizes endogenous levels of Aβ-40 peptide.
Purification Method	Protein A and immunogen affinity purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Polyclonal
Background	β-Amyloid (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage. The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease. APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein. Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase. APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation. β -amyloid (1-40) Rabbit pAb recognizes endogenous levels of Aβ-40 peptide.
Cellular Localization	Membrane

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Menge: 100 ul

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Lieferung vsl. bis 19.02.2026

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