Anti-ITK Mouse mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Interleukin-2 inducible T cell kinase (ITK, Emt or Tsk) is a member of the non-receptor protein tyrosine kinases. Family members of Itk include Tec, Btk, Rlk, and Bmx and are all defined by a common structure: an amino-terminal PH domain, a Tec-homology domain, and an SH3 and SH2 domain followed by a carboxy-terminal kinase domain. Tec, Rlk, and ITK are expressed in T cells and activated in response to T cell receptor (TCR) engagement. Data demonstrate that ITK functions in signal transduction downstream of TCR and activates PLCgamma1 and Erk. Lck directly activates ITK through phosphorylation in the conserved activation loop at Tyr511, and furthermore, ITK is autophosphorylated in the SH3 domain at Tyr180. ITK-Y180F is still capable of phosphorylating PLCgamma1 in contrast to ITK-Y511F, which has lost that function. Itk -/- mice show reduced lung inflammation, eosinophil infiltration, and mucous production in response to allergic asthma induction. Thus, ITK could become a desirable target for anti-asthmatic treatments.

PBS, Glycerol, BSA

Recombinant Monoclonal

Cytoplasm, Nucleus