Anti-TBK1/NAK Rabbit mAb

Uncategorized

Ambient temperature

84

TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through directphosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIKand IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κBactivation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immuneresponse (3).

PBS, Glycerol, BSA

Recombinant Monoclonal