Anti-RUNX1/AML1 Rabbit mAb

Primary Antibodies

RUNX1/AML1

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors. It is requiredfor normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβandregulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoieticcancers: chromosomal translocations include AML1-ETO, TEL-AML, and AML-M2. Phosphorylation of AML1 on several potential serine andthreonine sites, including Ser249, is thought to occur in an Erk-dependent manner.

PBS, Glycerol, BSA

Recombinant Monoclonal