Anti-c-Myc Rabbit mAb

Primary Antibodies

c-Myc

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior, includingproliferation, differentiation, and apoptosis. These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif requiredfor dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for theability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptionalnetwork, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max andeither Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3, and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Madproteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes, such as proliferation, transformation, and prevention of apoptosis by inhibiting transcription.

PBS, Glycerol, BSA

Recombinant Monoclonal