Mouse anti-IL-10 [+Biotin]

Hersteller Raybiotech
Kategorie
Typ Antibody
Specific against Human
Isotype IgG1
Format Supplied as lyophilized purified antibody. It can be reconstituted with sterile PBS before use. Please avoid freeze-thaw cycles.
Applikationen ELISA
Menge 50 ug
Host Mouse
ArtNr RB-IP-01-112B-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Target Name
IL-10
Accession Number
NM_000572
Conjugate/Tag/Label
Biotin
Application notes:
ELISA (recommended work dilution= For Sandwich-based ELISA and membranebased assay, detecting level is up to 1pg/ml when it is used for capture), Western Blotting (recommended work dilution= 0.1-0.2 ug/ml)
Product Description
Interleukin 10, or IL-10, is a 178 amino acid protein that is primarily secreted by TH2 clones. IL-10 has dual functions, the first of which is the suppression of cytokine production by TH1 clones responding to antigen presented by monocyte and macrophage antigen presenting cells (APCs). The second function consists of the inhibition of response of cytokine targeted cells, possibly by the downregulation of CD25 (the interleukin-2 receptor) on macrophages and B lymphocytes. Human and murine IL-10 exhibit 81% sequence identity at the amino acid level, and share 73% identity at the cDNA level. Both human and murine IL-10 are acid-liable and exist as non-covalently-linked homodimers in solution. IL-10 exerts its biological activity through the IL-10 receptor (IL-10R), a 560 amino acid, glycoprotein whose expression can be induced in cultured macro phages and fibroblasts by lipopolysaccharide (LPS) stimulation. IL-10 expression has been shown to be elevated in HIV-1 infected individuals and has been implicated in the progression of the disease.
Immunogen
Immunogen was recombinant protein derived from human IL-10. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G affinity chromatography.

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Menge: 50 ug
Lieferbar: In stock
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