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Mouse anti-IL-15 [+Biotin]

Mouse anti-IL-15 [+Biotin]

Hersteller	Raybiotech
Kategorie	Antibody Oncology Heart & Blood Cancer
Typ	Antibody
Specific against	Human
Isotype	IgG1
Format	Supplied as 100 ul of purified antibody in sterile PBS (pH 7.5), containing 0.1% BSA. The final concentration is indicated on the shipping vial. Please avoid freeze-thaw cycles.
Applikationen	ELISA
Menge	50 ug
Host	Mouse
ArtNr	RB-IP-01-115B-50
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Target Name	IL-15
Accession Number	NP_000576
Conjugate/Tag/Label	Biotin
Application notes:	ELISA (recommended work dilution= 1: 1, 000-4, 000), Western Blotting( recommended work dilution= 1-2 ug/ml)
Product Description	IL-15 is produced largely by dendritic cells, monocytes, andstromal cells. The IL-15R complex consists of three chains, IL-15R , IL-2/15Rbeta, and C chains. IL-15 binds the endogenous IL-15R chain expressed by IL-15-producing cells and is trans-presented to the complex of IL-2/15Rbeta and C chains with the signaling capacity expressed on T cells. The recognition of IL-15 by the latter receptor chains leads to the activationof various signaling pathways including JAK1 and 3/STAT5 aswell as PI3K/AKT. IL-15 has diverse functions that include promoting cytotoxicity and maintenance of memory CD8+ T cells as well as proliferation and differentiationof NK and NK T cells.
Immunogen	Immunogen was whole expressing mouse IL-15. This antibody was obtained from a mice immunized with the immunogen, then fusion, selection and identification. This antibody was produced from a hybridoma resulting from the fusion of a myeloma with B cells deriveded from the immunized mouse. The IgG fraction of cell culture supernatant was purified by Protein G affinity chromatography.

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