P11 (His-Ser-Asp-Val-His-Lys-NH2, Potent antagonist of alphavbeta3-vitronectin Interaction, Antiangiogenic)

Blue Ice

720, 78

Supplied as a white solid.

Potent antagonist of the integrin avb3-vitronectin interaction (IC50 = 25.72nm). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Sequence:
His-Ser-Asp-Val-His-Lys-NH2

Solubility:
20% acetonitrile, 0.1% acetic acid (~1mg/ml)

Molecular Weight:
~720.78

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.