TC HSD 21 (5-[(3-Bromo-4-hydroxyphenyl)methyle­ne]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone)

Blue Ice

422, 32

Supplied as a yellow solid.

Potent 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitor (IC50 values are 6 and 40nm at human and mouse 17beta-HSD3 respectively). Displays no activity at 17beta-HSD1, 17beta-HSD2, ERalpha, androgen receptors or glucocorticoid receptors.

Sequence:
C17H12BrNO3S2

Solubility:
DMSO (~100mM)

Molecular Weight:
~422.32

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.