Silver Bullets

0.5 mL of each 96 Silver Bullets reagent in a 96 deep well polypropylene microplate.
Silver Bullets screens a portfolio of small molecules for their ability to establish stabilizing, inter molecular, hydrogen bonding, hydrophobic and electrostatic interactions which could promote stability, lattice formation, and crystallization.
Published results with the Silver Bullets have been very encouraging, with more than twice as many proteins being crystallized overall as were crystallized from controls free of any small molecules. X-ray diffraction analysis has revealed the small molecule Silver Bullets in the crystal lattice, involved at the centers of hydrogen bonding networks and electrostatic interaction. Silver Bullets is compatible with hanging, sitting and sandwich drop vapor diffusion, microbatch, free interface, and microdialysis crystallization methods. Silver Bullets can be used with Dynamic Light Scattering (DLS), ThermoFluor, and Size Exclusion Chromatography assays.
Silver Bullets reagent portfolio:
-Organic salts and acids
-Biologically active small molecules
-Amino acids and peptides
-Macromolecular digests.
The Silver Bullets kit is a library of small molecules that have been shown to promote crystal lattice formation. X-ray diffraction analysis has demonstrated the reagents have the ability to:
-Stabilize the conformation of the protein
-Perturb the interaction of the protein with the solvent
-Participate in forming important lattice contacts
-Build the crystal lattice by forming reversible cross-links between the macromolecules in the crystal.