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Anti-2-Hydroxyisobutyryllysine Antibody Conjugated Agarose Beads

ArtNr PTM-804
Hersteller PTM Biolabs
Menge 500 ul
Kategorie
Typ Antibody Conjugated Beads
Format Liquid
Applikationen IA
Specific against other
Isotype IgG
Konjugat/Tag Agarose
Dry ice Yes
Citations Qing Li, et al. Lysine 2-hydroxyisobutyrylation proteomics analyses reveal the regulatory mechanism of CaMYB61-CaAFR1 module in regulating stem development in Capsicum annuum L.. PLANT JOURNAL, 2024. https://onlinelibrary.wiley.com/doi/abs/10.1111/tpj.16815.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 41105507
Alias khib
Versandbedingung Trockeneis
Lieferbar
Manufacturer - Type
Primary Antibodies
Manufacturer - Applications
IAP
Manufacturer - Category
Pan PTM Antibodies
Shipping Temperature
Cold packs / dry ice
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
Multiple
Stability
Stable for 12 months from date of receipt.
Manufacturer - Research Area
Post-Translational Modificaiton
Manufacturer - Reactivity
All
Product description
Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc. 2-Hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation.
Manufacturer - Specificity
With a mixture of high-quality rabbit- and mouse-derived anti-crotonyllysine antibodies cross-linked, this Anti-Phosphotyrosine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing crotonyllysine residues but do not cross-react with the peptides/proteins bearing structurally similar acetyllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine crotonylation.
Formula
Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody.
PTM
2-Hydroxyisobutyryl
Modification Site
Lys
Immunogen
2-Hydroxyisobutyrylated lysine peptides
Clonality
Polyclonal/Monoclonal
Background
Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc. 2-Hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ul
Lieferbar: In stock
lieferbar

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