FAS Ligand, soluble

ArtNr	RLT-100-157
Hersteller	ReliaTech
Menge	10ug
Kategorie	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis Enzymes Fatty Acid Synthesis
Typ	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	CHO cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	FASLG, FASL, CD178, CD95L, CD95-L, TNFSF6, APT1LG1 S1697
Lieferbar
NCBI Gene ID	356
Uniprot	P48023
Biological Activity	Determined by it's ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The ED50 for this effect is = 10.0 ng/ml, corresponding to a specific activity of = 1 x 105 units/mg.
Description	Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells which leads to down-regulation of the immune response. The mechanism of Fas induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. Both human and murine sFasL are fully active on human and murine cells. Recombinant human soluble Fas Ligand is a 17.9 kDa protein (175 amino acid residues) comprising the TNF homologous region of FasL plus an eight His-Tag.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Label	His-Tag
Length [aa]	156
Molecular Weight	17.9 kDa
mRNA RefSeq	NM_000639.1
Protein RefSeq	NP_035254
Protein Sequence	HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL
Purity Confirmation	>95% by SDS-PAGE & HPLC analysis
Synonyms	FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1 S1697
Uniprot ID	P48023

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