IGF-BP3

ArtNr	RLT-100-199S
Hersteller	ReliaTech
Menge	5ug
Kategorie	Oncology Metabolism Diabetes Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Senescence By Organ Breast Cancer
Typ	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IGFBP3, IBP3, BP-53
Lieferbar
NCBI Gene ID	3486
Uniprot	P17936
Biological Activity	The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is = 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
Description	Human IGF-BP3, also known as growth-hormone-dependant binding protein, is 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in alpha-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	264
Molecular Weight	28.8 kDa
mRNA RefSeq	NM_001013398
Protein RefSeq	NP_001013416
Protein Sequence	GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KR
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IGFBP3; IBP3; BP-53
Uniprot ID	P17936

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