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Follistatin like-protein 1/FSTL1 Europäischer Partner

ArtNr RLT-100-437S
Hersteller ReliaTech
Menge 10ug
Kategorie
Typ Cytokines and Growth Factors
Format Lyophilized
Specific against Human (Homo sapiens)
Host CHO cells
ECLASS 10.1 42030690
ECLASS 11.0 42030690
UNSPSC 12352202
Alias Follistatin-like protein 1, FSL1, Follistatin-related protein 1, FRP, OCC1, OCC-1, TGF-beta1-stimulated clone 36, TSC-36
Lieferbar
NCBI Gene ID
11167
Uniprot
Q12841
Biological Activity
Measured by its binding ability in a functional ELISA. When recombinant human Follistatin like 1/FSTL1 is coated at 200 ng/well, the concentration of recombinant human BMP-4 that produces 50% of the optimal binding response is found to be approximately 250 ng/mL.
Description
Follistatin-like protein 1 (FSTL1) is a widely-expressed, extracellular glycoprotein that is homologously grouped into the osteonectin (BM-40/SPARC) family of secreted proteins based on its possession of both a follistatin-like and extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in a cloned mouse osteoblast cell line, FSTL1 has since been implicated in an array of cell-type-specific functions, such as the regulation of proliferation, differentiation, apoptosis and migration, as well as a number of biological processes, including embryonic development, inflammatory response, angiogenesis, tumorigenesis, and immune disease pathogenesis. Highly conserved across mammalian species and widely expressed in human tissues, FSTL1 can be upregulated through signaling mediators of the innate immune system, such as TLR4 agonists and the arthritogenic cytokine IL-1beta via NF?B pathways, to stimulate the expression and secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, IL-6 and IL-8. While cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its resultant enzymatic cleavage of active IL-1beta from pro-IL-1beta. Whereas the overexpression of FSTL1 has been noted as a substantial contributor to the progression of immune diseases like rheumatoid arthritis (RA) and osteoarthritis (OA), diminished FSTL1 serum levels have been identified as playing a significant part in both ovarian and endometrial carcinogenesis, where it directly affects cell proliferation, migration and invasion. The CHO cell-derived recombinant human FSTL1 is a 288-amino-acid-length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under both reducing and non-reducing conditions.
Endotoxin Levels
< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]
288
Molecular Weight
50-55 kDa
mRNA RefSeq
NM_007085.4
Protein RefSeq
NP-009016.1
Protein Sequence
EEELRSKSKI CANVFCGAGR ECAVTEKGEP TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC NR
Purity Confirmation
> 95% by SDS-PAGE & HPLC analyses
Synonyms
Follistatin-like protein 1, FSL1, Follistatin-related protein 1, FRP, OCC1, OCC-1, TGF-ß1-stimulated clone 36, TSC-36
Uniprot ID
Q12841

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Menge: 10ug
Lieferbar: In stock
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