Anti-Phospho-Alpha synuclein (Ser129) antibody (KLH)

Polyclonal

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.

P37377

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that 129 phosphorylation of alpha-synuclein at ser plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 conjugated to KLH.

Cytoplasm
Membrane
Nucleus
Cell Junction
Synapse
Secreted
Membrane-Bound In Dopaminergic Neurons

WB 1:1000

Alpha-Synuclein

SYUA_RAT